2/29/2024 0 Comments Neoprobe sentinel node biopsy2013 310(14): 1455–61Ĭaudle AS, Yang WT, Krishnamurthy S, Mittendorf EA, Black DM, Gilcrease MZ et al. The ACOSOG Z1071 (Alliance) Clinical Trial. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer. īoughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B et al. Sentinel Node Biopsy After neoadjuvant Chemotherapy in Biopsy-Proven Node positive Breast Cancer: the SN FNAC Study. 2013 14(7): 609–18.īoileau JF, Poirier B, Basik M, Holloway CMB, Gaboury L, Sideris L et al. Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study. Kuehn T, Bauerfeind I, Fehm T, Fleige B, Hausschild M, Helms G et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. Von Minckwitz G, Untch M, Blohmer JU, Costa SD, Aidtmann H, Fasching PA, et al. Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. Rastogi P, Anderson SJ, Bear HD, Geer CE, Kahlenberg MS, Robidoux A et al. This procedure has enabled the suppression of ALND for a significant number of patients (73%). Similarly, our study allows us to conclude that combined axillary marking (clip and SLNB) in patients with metastatic lymph node at diagnosis and NAC offers a high identification rate (100%) and a high correlation between the wire-marked lymph node and the SLN (80%). Most of the studies reported high identification rates (> 94.8%), with false negative rates of < 7%. Several studies have evaluated the efficacy of various procedures for lymph node marking for women with prechemotherapy lymph node involvement. The SLN and wire-marked node matched in 80% of patients 73.8% of patients did not undergo ALND. We identified and extirpated the clip/wire-marked node in all patients (100%), with SLNB performed successfully in 95.3% of patients. Resultsįorty-two patients met the inclusion criteria. The multidisciplinary committee agreed on axillary treatment for patients with lymph node involvement. All patients who presented no metastatic involvement of the sentinel lymph node (SLN) or clip/wire-marked lymph node were spared an axillary lymph node dissection (ALND). We conducted a prospective study in which lymph node staging was performed using wire localization of positive lymph nodes and an SLNB with dual tracer. The aim of this study was to analyze the feasibility of wire/clip localization and sentinel lymph node biopsy (SLNB) for the axillary staging of these patients. The ideal technique for lymph node staging for patients with pathologically confirmed node-positive breast cancer at diagnosis and neoadjuvant chemotherapy (NAC) is unclear.
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